The Molecular Microbiology and Immunology Department at Oregon Health and Science University is committed to providing excellent research training for postdoctoral fellows. The candidate will benefit from both the highly interactive group of PIs within the MMI department that focus on host-pathogen interactions and the close group of TB research laboratories in the OHSU community. Duties of the position include: - Use a wide range of molecular, biochemical, and microbiological techniques to advance scientific knowledge of mycobacterial biology and aid in the drug discovery process. - Conduct experiments, and collect and analyze experimental data for the research project. - Maintain a laboratory book reporting all research conducted as part of project. - Prepare and present papers, reports, and presentations of current research work. - Participate in preparation of grant applications. Additional safety training will be required to work with cell lines/ infectious bacteria or viruses/ working with in a BSL-3/ABSL3 laboratory. Personal protective equipment must be worn as required. (Gloves, mask/respirator, eyewear, lab coat,  etc). This position must be able to become medically qualified to wear respiratory and protection equipment in a BSL3/ABSL3 laboratory. Vaccination against various pathogens as required by regulatory agencies or IBC, is required.

Two positions are available.   The Postdoc will work on multiple research projects related to lipid metabolism, macrophages, and atherosclerosis using techniques ranging from small animal physiology to cell culture, biochemistry, molecular biology, histology, and flow cytometry. This is a collaborative role that will work, teach and learn with research assistants, graduate students, and other postdocs and interacts with the Principal Investigator and other PIs and collaborators. The Postdoc will assist in developing methods as required by the project’s progress, and integrate with the KCVI/OHSU network of cores and laboratory expertise to maximize efficiency and reduce experimental costs. The Postdoc will also assemble, analyze, interpret, and organize data into scientific presentations including original papers.  Recent graduates are welcome.   Salary for this position aligns with the NIH Scale.

Duties of this position include: - Bioinformatics tool development - Collaborative omics analysis - Dissemination and Outreach   Travel may be necessary on occasion. Compensation for this position follows the NIH Salary Scale.

A postdoctoral position is immediately available in the DeFilippis laboratory of the Vaccine and Gene Therapy Institute. Our collaborative group studies the innate immune response as mediated by the cGAS-STING pathway and transformative ways in which it can be harnessed to enhance viral vaccines and anti-cancer therapeutics. For this we employ novel vaccines against SARS-CoV-2 as well as various emerging mosquito-transmitted viruses. We routinely use knockout and genetically humanized mouse models to characterize mechanisms that direct antiviral immunity and anti-tumor responses. These models are also used in concert with nonhuman primates to develop and demonstrate efficacy of novel STING-inducing vaccine and therapeutic platforms. Ultimately our work aims to synthesize molecular, cellular, and organismal observations to understand phenomena that enhance clinical outcomes.   The primary responsibilities of this position include 1) Mouse experimentation involving examination of adaptive and innate immune processes associated with protective vaccination and tumor immunity; 2) Molecular characterization of innate immune signaling processes and phenotypes using in vitro and ex vivo assays; 3) Utilization of CRISPR/Cas9 genome editing technology along with lentivector-mediated gene delivery to construct knock-in and knockout cell lines. Secondary responsibilities will include tasks related to the general support of laboratory function, mentoring, and collaboration. Experience working with small animal models strongly preferred.   Numerous opportunities exist for skills acquisition and independent project development. The ideal candidate requires minimal supervision, exercises judgment in taking self-directed action and seeks advice as necessary. Excellent recordkeeping and organizational skills required. Project leadership involving directing specific components of key research projects, actively maintaining a contemporary understanding of published developments in relevant research fields, demonstration of creativity and problem-solving ability, training and directing students and junior staff.

The Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking a highly motivated and enthusiastic post-doctoral fellow to study adeno-associated virus (AAV) and its application for human gene therapy in the lab led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can lead productively projects that aimed at developing novel AAV capsids using TRADE (TRanscirption-dependent Directed Evolution), a novel non-coding mRNA-based AAV capsid engineering method established in the Nakai lab, and studying their applications using various animal models. In addition, the successful candidate will participate in studies that intensively investigate the biology of AAV to understand the fundamental principles behind the virus-host interactions relevant to the development of novel molecular therapies for various diseases. There are various opportunities for post-doctoral fellows to lead currently ongoing projects and new projects.   Salary for this position aligns with the NIH Scale.

For physical therapists who aspire to become leaders in the specialty of pediatrics we offer a full-time one-year residency at the Child Development and Rehabilitation Center (CDRC) at the OHSU Institute on Development & Disability.    The Physical Therapy (PT) Residency functions within the Leadership Education in Neurodevelopmental and Related Disabilities (LEND) program. The LEND program promotes leadership, research skills, and clinical expertise in graduate level health care professionals who intend to devote their careers to working with children, youth and adults with a variety of health conditions including developmental disabilities. This residency program is credentialed by the American Physical Therapy Association.

Contribute to the development of new concepts, techniques and standards. Analyzes research data and provides interpretations.  Setup experimental and pre-clinic system.  Build advanced OCT systems, such as ultrahigh speed system, ultrahigh resolution system and collect preliminary results for grant application /paper publication. Setup functional OCT system, such as optical coherence elastography, and perform phantom / ex-vivo/in-vivo study with the system.  May involve several different projects.  Grade OCTs in CEI Reading Center.  Contributes to the development of research documentation for publication and/or prepares technique reports, papers and grant applications. Analyze research data and provide interpretation.  Contribute to the development of research documentation for publication and/or prepare technique reports, papers and grant applications. Operate and maintain sophisticated laboratory/scientific equipment.

The Postdoctoral Fellow will join a laboratory that is studying the central nervous system mechanisms of involuntary weight loss and wasting (cachexia) during the development of cancer.  The project involves the use of in vitro and murine models to understand the impact of peripheral cancers on autonomic nervous system function in the periphery. This project also has an associated clinical trial that will provide samples and data to confirm the basic hypotheses generated in the preclinical work. This NIH-funded study will define mechanisms of autonomic nervous system plasticity in the setting of chronic stress and inflammation, and will test novel therapeutics to address this debilitating condition.     Daily responsibilities include designing and conducting experiments, data acquisition and analysis, record-keeping and attending weekly lab meetings to present research findings. The postdoctoral fellow will also be required to produce scholarly manuscripts detailing results of ongoing studies.

The successful candidate will work independently to molecular mechanisms used by different oral microbes to communicate with each other and to create robust biofilms within the oral cavity and other body sites. The study involves the understanding of how oral commensal bacteria can interact with potential pathogens to modulate their virulence properties.  He/she will be responsible for most of the planning, implementation, and data interpretation associated with his/her research. Thus, the candidate will be expected to work independently with attention to detail and strong record-keeping. The goal is to understand what signals the commensal sends to keep the pathogens in check and what factors may upset pathogens to enhance their virulence.  Typical techniques often involved include real-time PCR, western blot, protein expression/purification, coimmunoprecipitation, protein-protein/RNA-RNA interaction assays, gene expression analysis, targeted mutagenesis, and microscopy. Demonstrable experience with these techniques is preferred. As a postdoctoral scholar, the candidate may also be involved with the training and supervision of students and junior staff as well as play an integral role in the management and supply ordering for the laboratory. Assistance with the development and preparation of grants/manuscripts will also be expected.  

We are seeking a recent PhD graduate or someone with postdoctoral experience to participate in research focused on understanding how herpes simplex virus (HSV) proteins and virus particles are transported in neuronal axons. The position will involve manipulating and producing plasmid DNAs, which will be transfected into neurons cells to produce HSV proteins that are transported into neuronal axons. Other work will involve studies of protein-protein interactions to understand which HSV proteins interact with kinesin motors that transport virus particles in axons. Specific duties include: - Manipulating and producing plasmid DNAs, which will be transfected into neurons to characterize protein transport into axons. - Producing virus stocks and using these viruses to infect neurons.  - Passaging and caring for neuronal cell lines and imaging these cells using confocal microscopy in order to determine how viruses and viral proteins are transported into neuronal axons. - Studying interactions between viral proteins and kinesin motors using molecular biologic techniques. - Assisting PI to write scientific papers and grant applications This position follows the NIH Salary Scale. The Postdoctoral Scholar will work in standard microbiology laboratory conditions, with exposures such as hazardous chemicals and biohazard waste.

Express and purify recombinant proteins and characterize their structure using a wide range of biophysical methods. Perform experiments as outlined in the PI’s grant to test the effect of deamidation and oxidation on the size of lens proteins using dynamic and static light scattering and determine the disulfide cross links using mass spectrometry. Perform structural studies using hydrogen/deuterium exchange with mass spectrometry.  Work cooperatively with the mass spectrometry core and collaborators elsewhere. Design, perform, and analyze experiments inline with PI’s NIH grant and expand into their own area of research.  Present findings at national and international meetings. Write and submit manuscripts for publication.  

The postdoctoral fellowship in neurodevelopment involves assessment, treatment, and research activities primarily within the Autism Program at the CDRC. Core assessment duties involve participation in interdisciplinary autism diagnostic clinic, providing differential diagnosis and treatment recommendations for children and youth (ages 1-18 years) with a referral question of Autism Spectrum Disorder.   Up to one-third of the fellow’s time may be spent in other assessment or treatment activities, such as a focus on neuropsychological evaluation in children with complex developmental and/or medical issues (e.g., neuro-oncology, epilepsy, traumatic brain injury), program development, inpatient consultation, behavioral treatment, parent training, or cognitive-behavioral individual/group/family treatment.   Research activities include participation on existing projects as well a s developing new and unique research projects based on area of interest and expertise.   The postdoctoral fellow will have access to a multitude of career development opportunities through the CDRC and OHSU, including a full range of didactic offerings. Opportunities to offer community based trainings to parents and service providers are available.

The postdoctoral researcher who will work on ongoing studies in nonhuman primate (NHP) models to study reproductive and perinatal health, impact of maternal environmental perturbations and effects of placental dysfunction. Our lab also utilizes advanced noninvasive in vivo imaging techniques and ultrasound-guided procedures to understand fetal development and placental function across gestation, and performs correlative in vitro studies in post-delivery samples to understand the impact of the in utero environment on placental adaptations and developmental processes in the fetus. Qualified candidates will hold a PhD in biology, physiology or equivalent and possess a comprehensive understanding of mammalian reproductive biology and molecular biology techniques. Applicants will be expected to develop skills related to the management of ongoing nonhuman studies, working directly with NHPs for behavioral observations, physiological and post-mortem sample collection. Applicants should be able to work in a team dynamic, carry out research unsupervised, keep up-to-date on relevant literature in the field, provide meaningful data reports for presentation at scientific meetings and prepare manuscripts.  Computer experience in Microsoft Word, Excel and statistical software is required. The applicant must have excellent organizational and communication skills, including the ability to interact effectively with investigators, clinicians and veterinary/husbandry staff. Salary will be based on postdoctoral NIH guidelines.

The Postdoctoral Scholar will work in the laboratory of Dr. Ninian Blackburn at Oregon Health & Sciences University, located in Portland Oregon.  The primary focus is on the structure function relationships in copper dependent monooxygenases such as peptidylglycine monooxygenase and dopamine β-monoxygenase which serve critical functions in neurobiology and signaling.  The emphasis will be on the mechanism of electron transfer, activation by substrate and the isolation and characterization of reactive oxygen intermediates again using advanced kinetic and spectroscopic techniques.  This position will likely provide guidance and supervision to students and lab technicians as appropriate. Duties of the position include, but are not limited to:   - Protein isolation and characterization with emphasis on determining metal concentrations and electronic structural properties - Measurements using  rapid kinetic methods including stopped-flow and rapid freeze quench techniques - Analysis of  rapid kinetic data - Spectroscopic measurements on metalloprotein structure/function, with an emphasis on X-ray spectroscopic techniques - Developing protocols for isolation of intermediates - Computer modeling with an emphasis on spectral simulation - Structure determination by x-ray crystallography and/or cryo-EM - General  biochemical laboratory techniques Evenings, weekends and extra hours may be required depending on the needs of the research. Approximately 3 times per year, the Postdoctoral Scholar will travel out of state to synchrotron facilities for 5 days per trip. This position will be working in an open wet lab environment, in the presence of laboratory chemicals and automated equipment. This position follows the NIH Salary Scale. 

This Postdoctoral Scholar position will work in a laboratory using in vitro slice electrophysiological, pharmacological and behavioral approaches to study brain mechanisms of pain and analgesia.  Primary duties include: - Design and perform experiments intended to elucidate brain mechanisms of pain modulation using electrophysiological recording and behavioral pharmacology - Perform histological reconstruction of recorded cells and sites, including immunohistochemical techniques - Analyze data, prepare manuscripts and present results at professional meetings

The Division of Pediatric Psychology at Oregon Health & Science University is recruiting for a full-time pediatric psychology postdoctoral fellow for the academic year 2022-2023   The postdoctoral fellowship is focused on working with young people with gastrointestinal disorders, including but not limited to Inflammatory Bowel Disease (IBD), Celiac Disease, Disorders of Gut Brain Interaction (Irritable Bowel Syndrome, Functional Abdominal Pain), and Constipation/Encopresis. This fellowship will provide opportunities for both inpatient and outpatient care and will involve working with a multidisciplinary team treating youth with gastrointestinal disorders. Training will emphasize collaboration and consultation with the division of Pediatric Gastroenterology focusing on symptom management, disease self-management, adjustment to a new diagnosis, preparation for transitioning from pediatric to adult care, and management of the psychosocial challenges which co-occur with gastrointestinal conditions. In addition, the position will involve research activities with opportunities to examine and study behavioral health screening in pediatric gastroenterology, healthcare transition, quality improvement, disease-distress, among others. The clinical and research activities can be tailored to the fellow’s interest and experience. Diversity is a pillar upon which our department and institution is built and we value recruiting trainees and faculty with diverse personal and professional experiences and perspectives. We are especially interested in outstanding applicants who are from groups underrepresented in medicine and psychology.   The postdoctoral fellow will have access to a multitude of career development opportunities through the Division of Pediatric Psychology, Institute on Development & Disability, and OHSU, including a full range of didactic offerings. Further, opportunities to offer community based trainings to parents, patients, and service providers are available.

Research involving animal models and human studies of ocular inflammatory diseases such as uveitis and age-related macular degeneration. Responsibilities will include animal husbandry, tracking and examination as well as animal model induction and treatments, tissue harvest and preparation; ex vivo assays such as ELISAs and flow cytometry will also be required.  Human specimens might also be handled (including serum and stool) for DNA isolation and sequencing. Other lab techniques such as western blot, immunohistochemistry &confocal microscopy, RT-PCR, and other common lab assays are part of the responsibilities for data collection. Keep accurate detailed records of all work done.  Compile data into spreadsheets and graphs; prepare reports for lab meetings; assist in the preparation of publications and grant submissions.

The Postdoc will perform research on projects as directed by Prof. Zuckerman to include one of more of the following:   - Statistical mechanics simulation and analysis methods for protein folding and/or binding, focusing on the weighted ensemble approach - A project with experimental collaborators investigating structural heterogeneity and allostery in a multivalent protein system, potentially involving molecular simulations and Bayesian inference with experimental data - Trajectory analysis of cell dynamics in collaboration with cancer biologists  - omputing as required on local and external resources, careful curation of all data, and development and maintenance of software on suitable repositories. Other duties include computing as required on local and external resources, careful curation of all data, attendance and presentation at lab meetings, contributions to publications and applications as requested, and presentations of successful research at one or more national or international meetings per year, as requested. 

Research is the primary focus of the Postdoctoral Researcher; however, typical duties and accountabilities include: - Embed and actively participate in high-performing research team under the guidance of a Research Faculty Mentor to drive health equity outcomes in patient-centered care.  - Gain experience in the process of publication and grant writing  - Presentation of project results to internal and external parties  - Participate in data analysis, and translation of results for clinical and policy relevance.  - Engage in appropriate training and professional development opportunities as desired by the individual, or required by the Principal Investigator, Department, or OHSU in order to develop research skills and professional competencies. Acquire generic and transferable skills (project management, business skills, mentorship and leadership skills, professionalism, etc.) 

A Post Doctoral Research position is available in the laboratory of Dr. Marina Guizzetti, Department of Behavioral Neuroscience.   The main research interest of Dr. Guizzetti’s laboratory is the identification of novel mechanisms of astrocyte-neuron interactions involved in neuronal plasticity in the developing and adult brain. We are particularly interested in the effects of alcohol exposure on astrocyte-specific gene expression and gene translation and how these changes alter normal brain development, potentially through alterations of the brain extracellular matrix (ECM). Key responsibilities include:   - Bench lab work relevant to assigned projects - Preparation of manuscripts - Assisting with preparation of funding proposals