Oregon Health & Science University

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Job Locations US-OR-Portland
Dr. Ginny Hsu’s laboratory is focus on Stem Cell based Tissue Engineering and Bone Biology. The lab is affiliated to OHSU Department of Orthodontics at OHSU School of Dentistry. Hsu lab is recruiting a Postdoc who can provide a full range of support in the research laboratory. Must be able to work effectively with the principal investigator and graduate students. The focus of this position will be studying perivascular stem cells in orthopedic tissue engineering and treatment for craniofacial skeletal disease.   A strong preference will be given to applicants with past experience or education in the development of stem cell and mineralization tissue expertise, proven record of taking initiative, and a strong educational background. Candidate with bioinformatics kills in mineralization tissue is also encouraged to apply.  The position includes a modest amount of basic laboratory operations (basic instrumentation maintenance, general laboratory support, biosafety, ordering materials and supplies), animal care, animal/human samples handling and support with editing grants/manuscripts.
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
School of Dentistry, Research
Postion Category
Postdoctoral
HR Mission
Academics
Requisition ID
2021-12871
Job Locations US-OR-Portland
- Plan and perform experiments related to the research goals of the lab - Interpret experiments - Write preliminary drafts of manuscripts - Attend and present at lab meetings and at local/national/international meetings Salary for this position aligns with the NIH Scale.
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Cell, Developmental and Cancer Biology
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-9454
Job Locations US-OR-Portland
Areas of research interest include clinical study design, control of image quality, image processing, image grading, control of data quality and completeness, missing data analysis, diagnostic accuracy analysis, longitudinal data analysis, survival analysis, regression analysis, disease progression analysis, and machine learning based on optical coherence tomography (OCT) and OCT angiography technologies.  Give presentations of research results.     Preparation of manuscript for journal publications.  Teach image processing, image grading, and statistics to research and clinical trainees. 
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Center for Ophthalmic Optics and Lasers Lab (Coollab), Casey Eye Institute, Department of Ophthalmology
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-14093
Job Locations US-OR-Portland
The behavioral health postdoctoral position emphasizes neuropsychological evaluation, consultation, treatment, and research activities within the Pediatric Critical Care & Neurotrauma Recovery Program (PCCNRP).   Clinical: The postdoctoral scholar will evaluate and provide outpatient and inpatient clinical services to patients with complex central nervous system (CNS) compromise (e.g., traumatic brain injury, brain infection, primary inflammatory conditions of the CNS, stroke, and seizure disorder). Patients are referred by PCCNRP physicians or seen in the hospital while inpatient. Services will be provided primarily at Doernbecher Children’s Hospital. Evaluations will include clinical interviews, neuropsychological assessment, and the communication of recommendations to members of the multidisciplinary team, patients and their caregivers, and other clinical and educational professionals in the community. Training will emphasize collaboration and consultation within the PCCNRP focusing on problems that present in inpatient medical care and post-discharge.   Research: Post Doc to perform tasks related to a R01 funded study through the National Institutes of Health. This person will perform tasks related to the intervention under study, data collection, study administrative duties and organizational tasks. The purpose of the study is to evaluate the effectiveness of a patient education and care navigator intervention to reduce disparities in outcomes among Hispanic youth with traumatic brain injury. The position requires collaboration with patients and families to teach them to interact effectively with the healthcare system by using digital health technologies. Coach providers in culturally effective communication and inform system-level improvements in partnership with community clinics. Addresses barriers, work to increase trust and self-efficacy among families accessing and navigating the health care system through the use of digital health technologies. Facilitate effective communication between families and their primary care physicians, Children’s health care providers, and the community.
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Institute on Development and Disability (IDD)
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-14059
Job Locations US-OR-Portland
Duties of this position include: - Bioinformatics tool development - Collaborative omics analysis - Dissemination and Outreach   Travel may be necessary on occasion. Compensation for this position follows the NIH Salary Scale.
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Biomedical Engineering/Computational Biology
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-14047
Job Locations US-OR-Beaverton
A postdoctoral position is immediately available in the DeFilippis laboratory of the Vaccine and Gene Therapy Institute. Our collaborative group studies the innate immune response as mediated by the cGAS-STING pathway and transformative ways in which it can be harnessed to enhance viral vaccines and anti-cancer therapeutics. For this we employ novel vaccines against SARS-CoV-2 as well as various emerging mosquito-transmitted viruses. We routinely use knockout and genetically humanized mouse models to characterize mechanisms that direct antiviral immunity and anti-tumor responses. These models are also used in concert with nonhuman primates to develop and demonstrate efficacy of novel STING-inducing vaccine and therapeutic platforms. Ultimately our work aims to synthesize molecular, cellular, and organismal observations to understand phenomena that enhance clinical outcomes.   The primary responsibilities of this position include 1) Mouse experimentation involving examination of adaptive and innate immune processes associated with protective vaccination and tumor immunity; 2) Molecular characterization of innate immune signaling processes and phenotypes using in vitro and ex vivo assays; 3) Utilization of CRISPR/Cas9 genome editing technology along with lentivector-mediated gene delivery to construct knock-in and knockout cell lines. Secondary responsibilities will include tasks related to the general support of laboratory function, mentoring, and collaboration. Experience working with small animal models strongly preferred.   Numerous opportunities exist for skills acquisition and independent project development. The ideal candidate requires minimal supervision, exercises judgment in taking self-directed action and seeks advice as necessary. Excellent recordkeeping and organizational skills required. Project leadership involving directing specific components of key research projects, actively maintaining a contemporary understanding of published developments in relevant research fields, demonstration of creativity and problem-solving ability, training and directing students and junior staff.
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Vaccine and Gene Therapy Institute
Postion Category
Research
HR Mission
Research
Requisition ID
2021-14016
Job Locations US-OR-Portland
- Planning, executing, and analyzing experiments for independent research project(s) using biochemical methods and single particle and tomographic cryo-EM methods to elucidate the structure of the serotonin and dopamine transporters and their organization at synapses. - Manuscript preparation for individual projects and assisting other lab members with manuscripts as needed. - Assisting the PI and other lab members with grant application (data acquisition, writing assistance, editing) as needed. - Traveling to national and international meetings to present on findings. - Helping to mentor and train junior members of the laboratory.
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Vollum Institute
Postion Category
Postdoctoral
HR Mission
Research
Requisition ID
2021-14012
Job Locations US-OR-Portland
The Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking a highly motivated and enthusiastic post-doctoral fellow to study adeno-associated virus (AAV) and its application for human gene therapy in the lab led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can lead productively projects that aimed at developing novel AAV capsids using TRADE (TRanscirption-dependent Directed Evolution), a novel non-coding mRNA-based AAV capsid engineering method established in the Nakai lab, and studying their applications using various animal models. In addition, the successful candidate will participate in studies that intensively investigate the biology of AAV to understand the fundamental principles behind the virus-host interactions relevant to the development of novel molecular therapies for various diseases. There are various opportunities for post-doctoral fellows to lead currently ongoing projects and new projects.   Salary for this position aligns with the NIH Scale.
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Molecular and Medical Genetics
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-8467
Job Locations US-OR-Portland
The Department of Molecular and Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking a highly motivated and enthusiastic Postdoctoral Scholar to study adeno-associated virus (AAV) and its application for human gene therapy in the lab led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can lead productively a newly funded NIH U01 project where we seek to develop clinically relevant novel AAV vectors and methods for in vivo regeneration of insulin-secreting beta cells in rhesus macaques and profoundly understand the mechanisms behind the technologies.   The Postdoctoral Scholar will join a multidisciplinary collaborative team and participate in global collaboration in the HIRN community, with an ultimate goal to develop AAV gene therapy for type I diabetes. The Postdoctoral Scholar will also contribute to the training of graduate, undergraduate, and high school students, as well as research staff.   Compensation for this position aligns with the NIH Scale.
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Molecular and Medical Genetics
Postion Category
Research
HR Mission
School of Medicine
Requisition ID
2020-5520
Job Locations US-OR-Portland
For physical therapists who aspire to become leaders in the specialty of pediatrics we offer a full-time one-year residency at the Child Development and Rehabilitation Center (CDRC) at the OHSU Institute on Development & Disability.    The Physical Therapy (PT) Residency functions within the Leadership Education in Neurodevelopmental and Related Disabilities (LEND) program. The LEND program promotes leadership, research skills, and clinical expertise in graduate level health care professionals who intend to devote their careers to working with children, youth and adults with a variety of health conditions including developmental disabilities. This residency program is credentialed by the American Physical Therapy Association.
Posting FTE
0.80
Position Type
Regular Part-Time
Posting Department
The Institute on Development and Disability (IDD)
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-13851
Job Locations US-OR-Portland
- Design and perform experiments related to chemistry, chemical genetics and proteomics of PARPs. - Data analysis and record keeping: Maintain accurate and detailed records of all experimental procedures, data collection and analysis performed. - Report experimental results, present at lab meetings, write manuscripts in preparation for publication, present research findings at scientific conferences. - Maintain high level of professional expertise through familiarity with current scientific literature. Participate in professional development opportunities. - As needed, provide guidance and training to others in the lab and/or project. May oversee the work of interns, students and other staff. - Other responsibilities as assigned by the supervisor in furtherance of the lab’s research and the university’s missions and goals of teaching, research, patient care, outreach and public service. This position follows the NIH Salary Scale.
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Chemical Physiology and Biochemistry
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-13844
Job Locations US-OR-Portland
Contribute to the development of new concepts, techniques and standards. Analyzes research data and provides interpretations.  Setup experimental and pre-clinic system.  Build advanced OCT systems, such as ultrahigh speed system, ultrahigh resolution system and collect preliminary results for grant application /paper publication. Setup functional OCT system, such as optical coherence elastography, and perform phantom / ex-vivo/in-vivo study with the system.  May involve several different projects.  Grade OCTs in CEI Reading Center.  Contributes to the development of research documentation for publication and/or prepares technique reports, papers and grant applications. Analyze research data and provide interpretation.  Contribute to the development of research documentation for publication and/or prepare technique reports, papers and grant applications. Operate and maintain sophisticated laboratory/scientific equipment.
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Casey Eye Institute, Department of Ophthalmology
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-8466
Job Locations US-OR-Portland
The Postdoctoral Fellow will join a laboratory that is studying the central nervous system mechanisms of involuntary weight loss and wasting (cachexia) during the development of cancer.  The project involves the use of in vitro and murine models to understand the impact of peripheral cancers on autonomic nervous system function in the periphery. This project also has an associated clinical trial that will provide samples and data to confirm the basic hypotheses generated in the preclinical work. This NIH-funded study will define mechanisms of autonomic nervous system plasticity in the setting of chronic stress and inflammation, and will test novel therapeutics to address this debilitating condition.     Daily responsibilities include designing and conducting experiments, data acquisition and analysis, record-keeping and attending weekly lab meetings to present research findings. The postdoctoral fellow will also be required to produce scholarly manuscripts detailing results of ongoing studies.
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Pediatrics
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-12727
Job Locations US-OR-Portland
The successful candidate will work independently to molecular mechanisms used by different oral microbes to communicate with each other and to create robust biofilms within the oral cavity and other body sites. The study involves the understanding of how oral commensal bacteria can interact with potential pathogens to modulate their virulence properties.  He/she will be responsible for most of the planning, implementation, and data interpretation associated with his/her research. Thus, the candidate will be expected to work independently with attention to detail and strong record-keeping. The goal is to understand what signals the commensal sends to keep the pathogens in check and what factors may upset pathogens to enhance their virulence.  Typical techniques often involved include real-time PCR, western blot, protein expression/purification, coimmunoprecipitation, protein-protein/RNA-RNA interaction assays, gene expression analysis, targeted mutagenesis, and microscopy. Demonstrable experience with these techniques is preferred. As a postdoctoral scholar, the candidate may also be involved with the training and supervision of students and junior staff as well as play an integral role in the management and supply ordering for the laboratory. Assistance with the development and preparation of grants/manuscripts will also be expected.  
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
School of Dentistry, Research
Postion Category
Postdoctoral
HR Mission
Academics
Requisition ID
2020-6137
Job Locations US-OR-Portland
A Postdoctoral position in Cell, Cancer or Molecular Biology is available at the Knight Cancer Institute's Center for Experimental Therapeutics (CET). Interested candidates are expected to have recently obtained their PhD and have a strong track record of publications in Cell, Cancer or Molecular biology. Job duties include performing research to understand the role of newly identified drivers in the pathogenesis of cancer so as to identify novel therapeutic targets. The translational research projects within CET leverage multi-disciplinary approach in biology, chemistry, pharmacology, molecular modeling, in vitro and patient-derived models to probe complex biological processes and to pursue new therapeutic opportunities for various diseases. As a member of multi-disciplinary team, the postdoctoral candidate will receive training in various aspects of drug discovery & development for his/her career development.   Duties Include: - Perform hands-on experiments (in vitro and in vivo) and analyze/interpret data on assigned projects - Critically evaluate relevant scientific advances and integrate this knowledge into research programs. Participate in project planning and execution - Publish research in peer-reviewed journals and present work at scientific conferences. Effectively write and/or communicate research and regulatory materials.  Attend and present at the project and group meetings and national conferences
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Knight Cancer Institute
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-13672
Job Locations US-OR-Portland
CEDAR funds its own research projects, expediting the process of discovery. Our research is milestone-driven to ensure that each project is fulfilling its stated goals. CEDAR is currently seeking applicants to fill 1-2 postdoctoral positions in the area of cancer cell biology and in particular mechanisms of cell state. CEDAR offers a unique opportunity for outstanding, driven, and creative postdoctoral fellows to perform cutting edge and high-risk research, ranging from understanding basic cancer biology to developing novel technologies to aid detection.   We are hiring a highly motivated Postdoctoral Scholar. As a CEDAR postdoc, you will work closely with Dr. Jungsun Kim and other CEDAR researchers to elucidate mechanisms that govern the establishment of cancer cell identity by utilizing a cellular reprogramming approach. Cell fate, or identity, is well-maintained through multiple chromatin states established by master transcription factors (TFs) and chromatin regulators. Dysregulation of the determination of cell identity may lead to tumorigenesis, and indeed dysregulated master TFs in cancer cells can dictate a cancer cell’s epigenetic landscape and cell state. A defined set of TFs can reprogram somatic cells into induced pluripotent stem cells (iPSCs) by rewiring the reversible epigenetic landscape of “starting” somatic cells, which is established by cell fate decisions during normal development. This led to the intriguing possibility that TF-mediated reprogramming may offer a tool to rewire and reverse aberrant epigenetic alterations in cancer cells. Indeed, we demonstrated a proof-principle of a pancreatic cancer reprogramming model that provides a human cell model for unprecedented experimental access to different stages of human pancreatic cancer. Using this system, we uncovered a regulatory network and a secreted or released protein that can discriminate early resectable stage I pancreatic cancer patients as well as all stages of PDAC from healthy controls (Kim et al., 2013 Cell Reports; Kim et al., 2017 Science Translational Medicine).     In this role you will conduct high rigorous research to define the early epigenetic changes that take place during cancer progression and will work to address the following questions; i) to what extent and how reproducibly aberrant cancer transcriptional networks can be destabilized through TF-mediated reprogramming, ii) how cells that fail reprogramming regain an aggressive tumor phenotype, and iii) what chromatin regulators maintain a cancer cell state. Addressing these questions will provide novel insight into how cancer cells establish and maintain cancer identity. Techniques you will use include next-generation sequencing (NGS) based tools such as ChIP-seq, RNA-seq, ATAC-seq, and single cell RNA-seq (Soufi et al; Cell 2015, Soufi et al; Cell 2012).   References 1. Kim J and Zaret KS et al., Science Translational Medicine 2017 Jul 12;9 (398) - Highlighted by Ray K. Nat Rev Gastroenterol Hepatol. 2017 doi: 10.1038/nrgastro.2017.111. - Highlighted by Talha Burki in Lancet Oncology News, 2017 July 20  - Featured in the CBS News, U.S.News & World Report, MSN Canada, The Japan Times, New China News, La Razón, Correio Braziliense News, Science Daily, NCI Cancer Current, and so on. -Selected as one of the Most Life-Changing Medical Breakthroughs of 2017 in Prevention magazine, 2017 Dec issue; The New Times magazine, 2017 Dec 25 2. Kim J and Zaret KS. The EMBO Journal 2015, 34: 739–747 3. Kim J and Zaret KS et al., 2013 Cell Reports 2013, 3: 2088–2099 -Highlighted in the Editor’s Choice in Science, vol 341, page 319, 2013 July 26 Featured in ESC & iPSC NEWS published by Connexon Creative, 2013 June 26 Highlighted in the Inside Life Science published by NIGMS, 2014 January 8
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Knight Cancer Institute
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-13671
Job Locations US-OR-Portland
We are currently hiring for highly motivated postdoctoral fellows to join Dr. Thuy Ngo’s lab. The goal of Dr. Ngo’s lab is to develop and deploy technologies for analyzing cfRNA, cfDNA, extracellular vesicles (EV) and protein complexes in body fluids for applications in precisiondiagnosis and selection of therapy. Ngo lab also seeks to understand the complex environment of molecular features detected in body fluids associated disease progression and the evolution of diseases in response to treatment. Furthermore, the lab is investigating the basic mechanism of EV medicated cell-cell communication, EV's content packaging and delivery. Candidates would work in the following areas. - Cell-free RNA and cell-free DNA methylation – Design experiments and perform sample preparation to sequence circulating RNA (mRNA, miRNA, transposable elements, circular RNA and microbiome) and DNA methylation from patient’s blood samples. Use existing tools and develop new methods to identify biomarkers, perform classification and prediction modelling, and analyze biological pathways associated with patient samples during cancer progression and under treatment. - Extracellular vesicles- Design experiments and perform sample preparation to analyze protein and RNA cargos of extracellular vesicles in body fluids and spent culture media. Investigate mechanism of EV biogenesis and delivery. - Developing new technologies for screening and measuring with low background, high sensitivity, high resolution and wide dynamic range to profile proteins and RNA cargos of EV and protein complexes, to characterize them physically and to measure them at both single complex level and at high a throughput manner.  - Transcriptome/Epigenome–Modeling and analyzing next-generation sequencing datasets that measure the transcriptome and the epigenome of cell-free RNA, cell-free DNA and extracellular vesicles in blood. Performing analysis of existing genomics data of cancerous cells to aid the design of cell-free RNA and cell-free DNA methylation assays. The successful candidate will use both existing tools and develop their own computational methods to analyze such datasets for characterization of healthy and cancerous patient populations. - Machine Learning/Statistics/Multiomics – Developing machine learning methods and statistical models for feature selection, classification, anomaly detection, time series analysis, and multiomics data integration.
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Knight Cancer Institute
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-13093
Job Locations US-OR-Portland
The Postdoctoral Scholar will have the opportunity to design and lead research projects for prioritizing therapies, selecting combination therapies, and evaluating resistance pathways in breast, ovarian, and endometrial cancers. Duties include: - Research project(s) in adaptive response to therapy in cancer. - Generally maintaining reproducible notebooks as needed for research projects. Includes ongoing methods of documentation, i.e. maintaining a dry lab notebook or GitHub code repositories. - Participating in lab meetings, making contributions and submitting research for publication, submitting applications for research funding, presenting research at seminars, poster sessions and conferences. Salary for this position aligns with the NIH Scale.
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
Cell, Developmental & Cancer Biology
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-11168
Job Locations US-OR-Portland
We are currently hiring a highly motivated fellow with expertise in Quantitative Bioimaging to work in one of the following areas. The successful candidate will be working with CEDAR and OHSU scientists including Xiaolin Nan and Fehmi Civitci initially and with increasing collaborations over time: - Large field superresolution microscopy imaging of tumor cells and tissues. We will develop an imaging and data analysis framework for analyzing tissues and cell populations using large-field superresolution microscopy. The goal is to capture early events in cancer initiation and progression (imaging tissue and tumor models) and to understand the importance of tumor heterogeneity in cancer development and response to therapy; - Multi-omic and multiplexed superresolution imaging of tumor cells and tissues. The emphasis is to extend current fluorescence (such as superresolution microscopy) to a multi-omic analysis tool for studying cancer progression in tissues and tumor models; - High-throughput single-molecule analysis of cancer biomarkers. The goal is to utilize and further develop our high-throughput single-molecule imaging platform for multiplexed cancer biomarker analysis with high sensitivity and specificity. Recent references: - Civitci et al. Fast and multiplexed superresolution imaging with DNA-PAINT-ERS. Nat. Comms. (2020). https://www.nature.com/articles/s41467-020-18181-6 - Lee et al. High-throughput single-particle tracking reveals nested membrane domains that dictates KRasG12D diffusion and trafficking. eLife (2019). http://doi.org/10.7554/eLife.46393 - Creech at al. Superresolution imaging of clinical formalin fixed paraffin embedded breast cancer with single molecule localization microscopy. Sci. Rep. (2017). https://doi.org/10.1038/srep40766; Duties Include: - Prepare manuscripts, and present research findings as abstracts or oral presentations (travel may be required) - Attend weekly group meetings and 1:1 meetings to: 1) present data and interpretation of results; 2) troubleshoot research results and 3) suggest next steps - Attend research related meetings including but not limited to Thursday PM SPORE seminars, Cancer Biology meetings, journal clubs - Perform experiments utilizing appropriate lab or computational techniques with proficiency, evaluate results, and determine the next steps to complete project and present data.  Think independently and problem solve. Stay on top of the literature and build skills to maximize the projects’ potential. - Duties as assigned
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
CEDAR - Knight Cancer Institute
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-8139
Job Locations US-OR-Portland
We are currently hiring for 1-2 highly motivated fellows with expertise in Cancer Biology to work in the following areas with a particular focus on Leukemia. Individuals with a strong background in Cancer Biology, Leukemia Biology or other related Molecular Biology discipline are encouraged to apply. Candidates would work with a range of CEDAR and OHSU scientists and clinicians conducting leukemia research. Cancer Epigenetics. Dysregulation or mutation of epigenetic regulators is an early event in leukemia development, yet the underlying mechanisms are poorly understood. Projects in this area will involve genomic and functional studies characterizing the epigenetic mechanisms of cancer using single cell and low input epigenetic methods in cell lines, genetically engineered mouse models and primary patient samples. Hematopoietic Stem Cell Biology. The earliest events in leukemia formation occur in the hematopoietic stem cell, leading to clonal expansion and facilitating the acquisition of subsequent transformative mutations. Projects in this area will investigate the impact of early leukemic mutations on stem cell function using both human and murine systems. Single Cell Multiomics Methodology Development. Early precancerous cells are subclonal populations surrounded by a large number of normal cells. Single cell sequencing methodologies are therefore well poised to interrogate these rare pre-malignant cells. A key component of this process will be linking multiple types of data to the same single cell including genotype, transcriptome, epigenome and proteome. Projects in this space will work to develop methodologies. Target Identification and Drug Development for Early Stage Blood Cancers. Specific mutations and mutation profiles are associated with an exceedingly high risk of progression from myelodysplastic syndrome and myeloproliferative neoplasms to acute myeloid leukemia. These include key epigenetic regulators and splicing factors. These mutations represent possible targets for early intervention. Projects in this area will identify key pathway dependencies produced by these mutations that are potentially targetable. These studies will use a variety of methodology including genome wide CRISPR screening, protein-protein interaction studies and a variety of molecular and cell biology techniques to validate targets.   Duties Include: - Prepare manuscripts, and present research findings as abstracts or oral presentations (travel may be required) - Attend weekly group meetings and 1:1 meetings to: 1) present data and interpretation of results; 2) troubleshoot research results and 3) suggest next steps - Attend research related meetings including but not limited to Thursday PM SPORE seminars, Cancer Biology meetings, journal clubs - Perform experiments utilizing appropriate lab or computational techniques with proficiency, evaluate results, and determine the next steps to complete project and present data.  Think independently and problem solve. Stay on top of the literature and build skills to maximize the projects’ potential. - Duties as assigned
Posting FTE
1.00
Position Type
Regular Full-Time
Posting Department
CEDAR - Knight Cancer Institute
Postion Category
Postdoctoral
HR Mission
School of Medicine
Requisition ID
2021-7938

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