The Vaccine and Gene Therapy Institute (VGTI) at Oregon Health & Science University (OHSU) has assembled a multidisciplinary team of scientists to respond to serious viral disease threats, including AIDS, chronic viral infection-associated diseases, newly emerging viral diseases and infectious diseases of the elderly. Our programs are intended to span the continuum between basic and clinical science, in which discoveries are rapidly advanced from the level of molecular and cellular biology through animal models and ultimately into clinical testing. The development of this unique program in immunology and virology provides an important training opportunity for graduate students and postdoctoral fellows at OHSU. This is why an important part of our mission is the training of young scientists in newer academic disciplines emerging at the Vaccine and Gene Therapy Institute.
A postdoctoral position is immediately available in the DeFilippis laboratory of the Vaccine and Gene Therapy Institute. Our collaborative group studies the innate immune response as mediated by the cGAS-STING pathway and transformative ways in which it can be harnessed to enhance viral vaccines and anti-cancer therapeutics. For this we employ novel vaccines against SARS-CoV-2 as well as various emerging mosquito-transmitted viruses. We routinely use knockout and genetically humanized mouse models to characterize mechanisms that direct antiviral immunity and anti-tumor responses. These models are also used in concert with nonhuman primates to develop and demonstrate efficacy of novel STING-inducing vaccine and therapeutic platforms. Ultimately our work aims to synthesize molecular, cellular, and organismal observations to understand phenomena that enhance clinical outcomes.
The primary responsibilities of this position include 1) Mouse experimentation involving examination of adaptive and innate immune processes associated with protective vaccination and tumor immunity; 2) Molecular characterization of innate immune signaling processes and phenotypes using in vitro and ex vivo assays; 3) Utilization of CRISPR/Cas9 genome editing technology along with lentivector-mediated gene delivery to construct knock-in and knockout cell lines. Secondary responsibilities will include tasks related to the general support of laboratory function, mentoring, and collaboration. Experience working with small animal models strongly preferred.
Numerous opportunities exist for skills acquisition and independent project development. The ideal candidate requires minimal supervision, exercises judgment in taking self-directed action and seeks advice as necessary. Excellent recordkeeping and organizational skills required. Project leadership involving directing specific components of key research projects, actively maintaining a contemporary understanding of published developments in relevant research fields, demonstration of creativity and problem-solving ability, training and directing students and junior staff.
Please note this is a position at OHSU West Campus (Beaverton). Submit a resume, cover letter and at least 3 references to be considered for this position.
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